I Am Legend starring Will Smith just opened. It's based on a story of the same name by Richard Matheson. In both the movie and story, Robert Neville survives a deadly disease that has wiped out most of mankind. Most, if not all of those remaining have been turned into Darkseekers, vampire-like creatures. Neville spends his time trying to find a cure for the disease as well as trying to survive in the hostile, post-apocalyptic world. This isn't the first time I Am Legend has been made into a movie. You can see Charlton Heston battles violent, light-sensitive albino mutants as he tries to find a cure for humanity in The Omega Man.
Actually, the story reminds me a lot of a book I'm reading by Max Brooks, World War Z. It's the oral history of those who survived a terrible virus that turned people into mindless zombies! The book is well writen and is very thought provoking.