As I'm normally a big fan of Brubaker/Phillips, I was quite surprised to find that Fatale wasn't really working for me. I had an unusual amount of difficulty keeping the characters straight and had to keep hunting through earlier chapters just to keep up with the story.
But I think the big issue is that Fatale has Lost syndrome. It raises question after mystery after enigma, with not an answer to be found. I found it tiring.
But everything is relative. Brubaker and Phillips are masters of their craft, and a poor effort by them is still pretty darned good by most standards.